HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylsulphamoyl chloride → 4-[Ethoxy(diphenyl)methyl]-N,N,5-trimethyl-1H-imidazole-1-sulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylsulphamoyl chloride | HCID 83372 | — |
| Reactant | Ethyl 4-methyl-5-imidazolcarboxylate | HCID 99200 | — |
| Reactant | 4-[Ethoxy(diphenyl)methyl]-5-methylimidazole | HCID 19825136 | — |
| Reactant | HCID 178418255 | HCID 178418255 | — |
| Product | 4-[Ethoxy(diphenyl)methyl]-N,N,5-trimethyl-1H-imidazole-1-sulfonamide | HCID 19825131 | — |
Reaction Steps
Ethyl 5-methylimidazole-4-carboxylate was converted by a Grignard reaction, using phenylmagnesium bromide, to 4-[ethoxy(diphenyl)methyl]-5-methylimidazole, m.p. 205°. This was then treated with dimethylsulphamoyl chloride in a similar manner to that described in Example 1, to give 1-dimethylsulphamoyl-4-[ethoxy(diphenyl)methyl)-5-methylimidazole, m.p. 150°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05045557 |
| Source dataset | uspto-grants-1991_09 |
| ORD ID | ord-522f1d64b4dc49f99eed7e9ba9e14333 |
| Source note | uspto-grants-1991_09 |