反应详情

2.79 g of 1-[1-(4-bromophenyl)-butyl]-imidazole and 1.8 g of copper(I) cyanide are heated in 5 ml of N-methylpyrrolidine for 4 hours at 180° C. under a protecting gas atmosphere (argon). After cooling, it is precipitated in 50 ml of ammonia solution, stirred for 15 more minutes at room temperature and extracted with ethyl acetate. After concentration by evaporation in a vacuum 1.95 g of dark oil is obtained. This oil is distilled on a bulb tube in a vacuum; boiling point 200°-215° C./0.05 mbar. The resulting distillate is recrystallized from ethanol/petroleum ether. 1.54 g of 4-[1-(1-imidazolyl)-butyl]-benzonitrile with a melting point of 63°-71° C. is obtained.

1. temperatureAfter cooling
2. customit is precipitated in 50 ml of ammonia solution
3. extractionextracted with ethyl acetate
4. concentrationAfter concentration
5. customby evaporation in a vacuum 1.95 g of dark oil
6. customis obtained
7. distillationThis oil is distilled on a bulb tube in a vacuum
8. customThe resulting distillate is recrystallized from ethanol/petroleum ether