1-[4-[1-(1-Imidazolyl)-butyl]-phenyl]-ethanol → 4'-[1-(1-Imidazolyl)-butyl]-acetophenone

HRID 727850Notes

Reaction equation

HRID 727850 reaction equation
[N:1]1([CH:6]([C:10]2[CH:15]=[CH:14][C:13]([CH:16]([OH:18])[CH3:17])=[CH:12][CH:11]=2)[CH2:7][CH2:8][CH3:9])[CH:5]=[CH:4][N:3]=[CH:2]1>C(Cl)Cl.[O-2].[O-2].[Mn+4]>[N:1]1([CH:6]([C:10]2[CH:11]=[CH:12][C:13]([C:16](=[O:18])[CH3:17])=[CH:14][CH:15]=2)[CH2:7][CH2:8][CH3:9])[CH:5]=[CH:4][N:3]=[CH:2]1

Participants

4

Reactant 1

HCID 198251771-[4-[1-(1-Imidazolyl)-butyl]-phenyl]-ethanol

Product 1

HCID 198251544'-[1-(1-Imidazolyl)-butyl]-acetophenoneYield 50.4%

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 6344DichloromethaneSolvent

Procedure

200 mg of the alcohol of example 7 is stirred in 10 ml of methylene chloride with 1 g of manganese dioxide overnight. It is suctioned off, concentrated by evaporation and the residue is distilled at 180° C./0.03 hPa. 100 mg of the title compound is obtained as colorless oil.

Workup

  1. concentrationconcentrated by evaporation
  2. distillationthe residue is distilled at 180° C./0.03 hPa

Sources & evidence

ORD record
ord-68934ef1a08b4ddeaccceb3e340fedc0
Source dataset
uspto-grants-1991_09
Patent number
US05045558

Reaction notes

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