HCID 54144148, compound → HCID 14514373, compound

HRID 727856Notes

Reaction equation

HRID 727856 reaction equation
[N:1]1([CH:6]([C:10]2[CH:11]=[C:12]([CH:18]=[CH:19][CH:20]=2)[CH:13]=[CH:14][C:15]([OH:17])=[O:16])[CH2:7][CH2:8][CH3:9])[CH:5]=[CH:4][N:3]=[CH:2]1.[H][H]>CO.[Pd]>[N:1]1([CH:6]([C:10]2[CH:11]=[C:12]([CH2:13][CH2:14][C:15]([OH:17])=[O:16])[CH:18]=[CH:19][CH:20]=2)[CH2:7][CH2:8][CH3:9])[CH:5]=[CH:4][N:3]=[CH:2]1

Participants

5

Reactant 2

HCID 54144148HCID 54144148, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 14514373HCID 14514373, compoundYield 96.5%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

1.08 g of 3-[1-(1-imidazolyl)-butyl]-cinnamic acid (example 42) is dissolved in 20 ml of methanol and mixed with 100 mg of palladium on carbon (10%) and hydrogenated at normal pressure. After 2 hours, the reaction mixture does not take up any more hydrogen. Then the catalyst is filtered off on kieselguhr and the filtrate is concentrated by evaporation in a vacuum. 1.05 g of 3-[3-[1-(1-imidazolyl)-butyl]-phenyl]propionic acid is obtained

Workup

  1. filtrationThen the catalyst is filtered off on kieselguhr
  2. concentrationthe filtrate is concentrated by evaporation in a vacuum

Sources & evidence

ORD record
ord-6abc96a3bef9496a8fb12a8eb5475320
Source dataset
uspto-grants-1991_09
Patent number
US05045558

Reaction notes

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