Hydroxyamine hydrochloride → 1-[1-(4-Hydroxyiminomethylphenyl)-butyl]-imidazole

HRID 727857Notes

Reaction equation

HRID 727857 reaction equation
[N:1]1([CH:6]([C:10]2[CH:17]=[CH:16][C:13]([CH:14]=O)=[CH:12][CH:11]=2)[CH2:7][CH2:8][CH3:9])[CH:5]=[CH:4][N:3]=[CH:2]1.Cl.[NH2:19][OH:20]>N1C=CC=CC=1>[OH:20][N:19]=[CH:14][C:13]1[CH:16]=[CH:17][C:10]([CH:6]([N:1]2[CH:5]=[CH:4][N:3]=[CH:2]2)[CH2:7][CH2:8][CH3:9])=[CH:11][CH:12]=1

Participants

4

Reactant 2

HCID 443297Hydroxyamine hydrochlorideHCID 145143774-[1-(1-Imidazolyl)butyl]-benzaldehyde

Product 1

HCID 867450251-[1-(4-Hydroxyiminomethylphenyl)-butyl]-imidazole

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

0.5 g of 4-[1-(1-imidazolyl)-butyl]-benzaldehyde (see example 6) is dissolved in 2 ml of pyridine and mixed with 0.215 g of hydroxylamine hydrochloride. It was stirred overnight at room temperature and precipitated in 30 ml of water and extracted with ether. After removal of the solvent under vacuum, 0.4 of 1-[1-(4-hydroxyiminomethylphenyl)-butyl]-imidazole is obtained as yellow oil.

Workup

  1. customprecipitated in 30 ml of water
  2. extractionextracted with ether
  3. customAfter removal of the solvent under vacuum, 0.4 of 1-[1-(4-hydroxyiminomethylphenyl)-butyl]-imidazole
  4. customis obtained as yellow oil

Sources & evidence

ORD record
ord-645d65666b3648b9a58d57d61ea72a11
Source dataset
uspto-grants-1991_09
Patent number
US05045558

Reaction notes

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