反应详情

0.5 g of 4-[1-(1-imidazolyl)-butyl]-benzaldehyde (of example 6) is dissolved with 0.42 g of O- methylhydroxylamine hydrochloride in 20 ml of pyridine and stirred overnight. It is poured into 100 ml of water and extracted with ethyl acetate. The organic phase is concentrated by evaporation in a vacuum and distilled on a bulb tube, boiling point 200° C./0.03 mbar. 0.39 g of 1-[1-(4-methoxyiminomethylphenyl)-butyl]imidazole is obtained.

1. extractionextracted with ethyl acetate
2. concentrationThe organic phase is concentrated by evaporation in a vacuum
3. distillationdistilled on a bulb tube