Triethylamine → HCID 22462389, compound

HRID 728014Notes

Reaction equation

HRID 728014 reaction equation
[CH2:1]([O:4][C:5]1[CH:13]=[CH:12][CH:11]=[CH:10][C:6]=1[C:7](Cl)=[O:8])[CH2:2][CH3:3].[NH2:14][C:15]1[C:16]([C:21]([NH2:23])=[O:22])=[N:17][CH:18]=[CH:19][CH:20]=1.C(N(CC)CC)C>C(#N)C>[CH2:1]([O:4][C:5]1[CH:13]=[CH:12][CH:11]=[CH:10][C:6]=1[C:7]([NH:14][C:15]1[C:16]([C:21]([NH2:23])=[O:22])=[N:17][CH:18]=[CH:19][CH:20]=1)=[O:8])[CH2:2][CH3:3]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 132387253-Amino-pyridine-2-carboxylic acid amideHCID 159219132-Propoxybenzoyl chloride

Product 1

HCID 22462389HCID 22462389, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

In a similar manner to Example 1 a) reaction of 2-propoxybenzoyl chloride (0.99 g), 3-aminopicolinamide (0.69 g) and triethylamine (0.51 g) in acetonitrile (15 ml) afforded a crude product which was recrystallised from methanol to afford 3-(2-propoxybenzamido)picolinamide, 0.91 g, m.p. 116°-118° C.

Workup

  1. customafforded a crude product which
  2. customwas recrystallised from methanol

Sources & evidence

ORD record
ord-f7a77a4ed6454e6ba2800ec30001d36c
Source dataset
uspto-grants-1991_09
Patent number
US05047404

Reaction notes

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