反应详情

In a similar manner to Example 18 reaction of 3-methylthio-5-chloro-6-carboethoxy-1,2,4-triazine (prepared from 3-methylthio-5-oxo-6-carboethoxy-4,5-dihydro-1,2,4-triazine, 1.5 g) with 2-isobutoxybenzamidine hydrochloride (2.37 g) and triethylamine (1.75 g) afforded the crude title compound (1.71 g). This was recrystallised from acetonitrile, then dissolved in chloroform, the organic solution was washed with 2 Normal hydrochloric acid (x 2), chloroform removed under reduced pressure and the residue recrystallised twice from ethanol to afford the title compound, 0.32 g, m.p. 237°-238° C.

1. customafforded the crude title compound (1.71 g)
2. customThis was recrystallised from acetonitrile
3. dissolutiondissolved in chloroform
4. washthe organic solution was washed with 2 Normal hydrochloric acid (x 2), chloroform
5. customremoved under reduced pressure
6. customthe residue recrystallised twice from ethanol