反应详情

温度

70 °C

A mixture comprising 6.5 g of N-methyl-2-(3,4-dimethoxyphenyl)ethylamine hydroiodide, 1.6 g of methacrylonitrile and 2.4 g of triethylamine was heated at about 70° C. for 2.5 hours and cooled, followed by the addition of dichloromethane. The obtained mixture was washed with water, dried over magnesium sulfate and distilled to remove the solvent. The residue was purified by silica gel column chromatography (solvent: dichloromethane/ethanol (100:1)) to obtain 2.1 g of 3-[N-methyl-N-(2-(3,4-dimethoxyphenyl)ethyl)-amino]-2-methylpropionitrile.

1. temperaturecooled
2. washThe obtained mixture was washed with water
3. dry with materialdried over magnesium sulfate
4. distillationdistilled
5. customto remove the solvent
6. customThe residue was purified by silica gel column chromatography (solvent: dichloromethane/ethanol (100:1))