Triethylamine → HCID 19979417, compound

HRID 728096Notes

Reaction equation

HRID 728096 reaction equation
[C:1](Cl)(=[O:4])[CH:2]=[CH2:3].[CH:6]1([O:12][N:13]2[C:18]([CH3:20])([CH3:19])[CH2:17][CH:16]([OH:21])[CH2:15][C:14]2([CH3:23])[CH3:22])[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]1.C(N(CC)CC)C>C(Cl)Cl>[CH:6]1([O:12][N:13]2[C:14]([CH3:23])([CH3:22])[CH2:15][CH:16]([O:21][C:1](=[O:4])[CH:2]=[CH2:3])[CH2:17][C:18]2([CH3:19])[CH3:20])[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11]1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 13140Acryloyl chlorideHCID 113228111-Cyclohexyloxy-2,2,6,6-tetramethyl-piperidin-4-ol

Product 1

HCID 19979417HCID 19979417, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

A solution of 1.6 ml of acryloyl chloride in 20 ml of methylene chloride is added to a stirred solution of 5.11 grams of 1-cyclohexyloxy-2,2,6,6-tetramethylpiperidin-4-ol and 3.10 ml of triethylamine in 20 ml of methylene chloride at 0° C. After stirring at room temperature for 2 hours, the solvent is removed under reduced pressure. The residue is then purified by liquid chromatography to afford the title compound as a white solid with a melting point of 49°-52° C.

Workup

  1. customthe solvent is removed under reduced pressure
  2. customThe residue is then purified by liquid chromatography

Sources & evidence

ORD record
ord-b7e17e4c9ace4172afd12ce0c101d0f3
Source dataset
uspto-grants-1991_09
Patent number
US05047489

Reaction notes

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