Methyl isothiocyanate → HCID 9970424, compound

HRID 728121Notes

Reaction equation

HRID 728121 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][N:11]=2)=[CH:4][CH:3]=1.[CH3:16][N:17]=[C:18]=[S:19]>C(O)C>[CH3:16][NH:17][C:18](=[S:19])[NH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][N:11]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 11167Methyl isothiocyanateHCID 2332894-[2-(Pyridin-2-yl)ethyl]aniline

Product 1

HCID 9970424HCID 9970424, compoundYield 92%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 2-[2-(4-aminophenyl)ethyl]pyridine (5.8 g) and methyl isothiocyanate (2.6 g) in ethanol (60 ml) was refluxed for one hour. The reaction mixture was evaporated in vacuo to give a crystalline residue, which was recrystallized from a mixture of ethyl acetate and diisopropyl ether to give 2-[2-{4-(3-methylthioureido)phenyl}ethyl]pyridine (7.3 g).

Workup

  1. customThe reaction mixture was evaporated in vacuo
  2. customto give a crystalline residue, which
  3. customwas recrystallized from a mixture of ethyl acetate and diisopropyl ether

Sources & evidence

ORD record
ord-2786915190ab40a69fda641934215733
Source dataset
uspto-grants-1991_09
Patent number
US05047411

Reaction notes

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