Ethyl isothiocyanate → HCID 15171496, compound

HRID 728123Notes

Reaction equation

HRID 728123 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][C:10]2[N:11]=[C:12]3[CH:17]=[C:16]([CH3:18])[CH:15]=[CH:14][N:13]3[C:19]=2[CH3:20])=[CH:4][CH:3]=1.[CH2:21]([N:23]=[C:24]=[S:25])[CH3:22]>C(O)C>[CH3:20][C:19]1[N:13]2[CH:14]=[CH:15][C:16]([CH3:18])=[CH:17][C:12]2=[N:11][C:10]=1[CH2:9][CH2:8][C:5]1[CH:6]=[CH:7][C:2]([NH:1][C:24]([NH:23][CH2:21][CH3:22])=[S:25])=[CH:3][CH:4]=1

Participants

4

Reactant 2

HCID 10966Ethyl isothiocyanateHCID 10422999HCID 10422999, compound

Product 1

HCID 15171496HCID 15171496, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 2-[2-(4-aminophenyl)ethyl]-3,7-dimethylimidazo[1,2-a]pyridine (2.2 g) and ethyl isothiocyanate (0.8 ml) in ethanol (20 ml) was refluxed for 1.5 hours. The solvent was evaporated and the residue was triturated with diethyl ether. The precipitate was collected by filtration and dried to give 3,7-dimethyl-2-[2-{4-(3-ethylthioureido)phenyl}ethyl]imidazo[1,2-a]pyridine (2.42 g).

Workup

  1. temperaturewas refluxed for 1.5 hours
  2. customThe solvent was evaporated
  3. customthe residue was triturated with diethyl ether
  4. filtrationThe precipitate was collected by filtration
  5. customdried

Sources & evidence

ORD record
ord-3767f4a68bf547ffa9e1e3c8f816d8b1
Source dataset
uspto-grants-1991_09
Patent number
US05047411

Reaction notes

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