Hydrochloric Acid → HCID 19823303, compound

HRID 728143Notes

Reaction equation

HRID 728143 reaction equation
[ClH:1].[CH3:2][C:3]1[N:7]2[CH:8]=[CH:9][C:10]([CH3:12])=[CH:11][C:6]2=[N:5][C:4]=1[CH2:13][CH2:14][C:15]1[CH:24]=[CH:23][C:18]2[N:19]=[C:20]([NH2:22])[O:21][C:17]=2[CH:16]=1>C(O)C>[ClH:1].[ClH:1].[CH3:2][C:3]1[N:7]2[CH:8]=[CH:9][C:10]([CH3:12])=[CH:11][C:6]2=[N:5][C:4]=1[CH2:13][CH2:14][C:15]1[CH:24]=[CH:23][C:18]2[N:19]=[C:20]([NH2:22])[O:21][C:17]=2[CH:16]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 15684553HCID 15684553, compound

Product 1

HCID 19823303HCID 19823303, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Conc. hydrochloric acid (1.1 ml) was added to a mixture of 6-[2-(3,7-dimethylimidazo[1,2-a]pyridin-2-yl)ethyl]-2-aminobenzoxazole (1.5 g) in ethanol (9 ml) and the mixture was stirred for 5 minutes at ambient temperature. The isolated crystal was collected by filtration and the resulting crystal was recrystallized from a mixture of ethanol and ethyl acetate to give 6-[2-(3,7-dimethylimidazo[1,2-a]pyridin-2-yl)ethyl]-2-aminobenzoxazole dihydrochloride (0.91 g).

Workup

  1. filtrationThe isolated crystal was collected by filtration
  2. customthe resulting crystal was recrystallized from a mixture of ethanol and ethyl acetate

Sources & evidence

ORD record
ord-f45f405398684f4f973d88b4ea97eaff
Source dataset
uspto-grants-1991_09
Patent number
US05047411

Reaction notes

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