Water → HCID 178492992, compound

Participants

Reaction Steps

A mixture of 2-amino-6-[2-(7-methoxy-3-methylimidazo[1,2-a]pyridin-2-yl)ethyl]benzoxazole dihydrochloride (2.0 g) in 1N hydrochloric acid (25.3 ml) was was refluxed for 21 hours. The reaction mixture was added to water (50 ml) under ice-cooling and the resulting precipitate was collected by filtration. A mixture of obtained residue and water was adjusted to pH 8 with 20% potassium carbonate aqueous solution under stirring. A precipitate was collected by filtration and dried to give 2-hydroxy-6-[2-(7-methoxy-3-methylimidazo[1,2-a]pyridin-2-yl)ethyl]benzoxazole (0.98 g).

Provenance & Evidence