Water → HCID 178492992, compound

HRID 728158Notes

Reaction equation

HRID 728158 reaction equation
Cl.Cl.N[C:4]1[O:5][C:6]2[CH:12]=[C:11]([CH2:13][CH2:14][C:15]3[N:16]=[C:17]4[CH:22]=[C:21]([O:23][CH3:24])[CH:20]=[CH:19][N:18]4[C:25]=3[CH3:26])[CH:10]=[CH:9][C:7]=2[N:8]=1.[OH2:27]>Cl>[OH:27][C:4]1[O:5][C:6]2[CH:12]=[C:11]([CH2:13][CH2:14][C:15]3[N:16]=[C:17]4[CH:22]=[C:21]([O:23][CH3:24])[CH:20]=[CH:19][N:18]4[C:25]=3[CH3:26])[CH:10]=[CH:9][C:7]=2[N:8]=1

Participants

4

Reactant 2

HCID 962WaterHCID 19823302HCID 19823302, compound

Product 1

HCID 178492992HCID 178492992, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A mixture of 2-amino-6-[2-(7-methoxy-3-methylimidazo[1,2-a]pyridin-2-yl)ethyl]benzoxazole dihydrochloride (2.0 g) in 1N hydrochloric acid (25.3 ml) was was refluxed for 21 hours. The reaction mixture was added to water (50 ml) under ice-cooling and the resulting precipitate was collected by filtration. A mixture of obtained residue and water was adjusted to pH 8 with 20% potassium carbonate aqueous solution under stirring. A precipitate was collected by filtration and dried to give 2-hydroxy-6-[2-(7-methoxy-3-methylimidazo[1,2-a]pyridin-2-yl)ethyl]benzoxazole (0.98 g).

Workup

  1. temperaturewas was refluxed for 21 hours
  2. temperaturecooling
  3. filtrationthe resulting precipitate was collected by filtration
  4. additionA mixture of obtained residue and water
  5. filtrationA precipitate was collected by filtration
  6. customdried

Sources & evidence

ORD record
ord-3d2be178d94e4fea946873ada7957690
Source dataset
uspto-grants-1991_09
Patent number
US05047411

Reaction notes

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