Hydrochloric Acid → HCID 19823322, compound

Participants

Reaction Steps

Conc. hydrochloric acid (0.6 ml) was added to a solution of 6-[2-(7-ethoxy-3-methylimidazo[1,2-a]pyridin-2-yl)ethyl]-2-aminobenzoxazole (1.0 g) in ethanol (6.0 ml) and the mixture was stirred for 1 hour at ambient temperature. The mixture was added to ethyl acetate (40 ml) and stirred. The resulting precipitate was collected by filtration and the residue was crystallized from a mixture of ethanol (6 ml) and ethyl acetate (3 ml) to give 6-[2-(7-ethoxy-3-methylimidazo[1,2-a]pyridin-2-yl)ethyl]-2-aminobenzoxazole dihydrochloride (0.92 g).

Provenance & Evidence