Hydrochloric Acid → HCID 19823322, compound

HRID 728162Notes

Reaction equation

HRID 728162 reaction equation
[ClH:1].[CH2:2]([O:4][C:5]1[CH:10]=[CH:9][N:8]2[C:11]([CH3:26])=[C:12]([CH2:14][CH2:15][C:16]3[CH:25]=[CH:24][C:19]4[N:20]=[C:21]([NH2:23])[O:22][C:18]=4[CH:17]=3)[N:13]=[C:7]2[CH:6]=1)[CH3:3].C(OCC)(=O)C>C(O)C>[ClH:1].[ClH:1].[CH2:2]([O:4][C:5]1[CH:10]=[CH:9][N:8]2[C:11]([CH3:26])=[C:12]([CH2:14][CH2:15][C:16]3[CH:25]=[CH:24][C:19]4[N:20]=[C:21]([NH2:23])[O:22][C:18]=4[CH:17]=3)[N:13]=[C:7]2[CH:6]=1)[CH3:3]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 8857Ethyl AcetateHCID 15684562HCID 15684562, compound

Product 1

HCID 19823322HCID 19823322, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Conc. hydrochloric acid (0.6 ml) was added to a solution of 6-[2-(7-ethoxy-3-methylimidazo[1,2-a]pyridin-2-yl)ethyl]-2-aminobenzoxazole (1.0 g) in ethanol (6.0 ml) and the mixture was stirred for 1 hour at ambient temperature. The mixture was added to ethyl acetate (40 ml) and stirred. The resulting precipitate was collected by filtration and the residue was crystallized from a mixture of ethanol (6 ml) and ethyl acetate (3 ml) to give 6-[2-(7-ethoxy-3-methylimidazo[1,2-a]pyridin-2-yl)ethyl]-2-aminobenzoxazole dihydrochloride (0.92 g).

Workup

  1. stirringstirred
  2. filtrationThe resulting precipitate was collected by filtration
  3. customthe residue was crystallized from a mixture of ethanol (6 ml) and ethyl acetate (3 ml)

Sources & evidence

ORD record
ord-9407b6e796c64f13866bbc4415054ffc
Source dataset
uspto-grants-1991_09
Patent number
US05047411

Reaction notes

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