反应详情

A mixture of [2-(N-ethylformamido)benzoxazol-6-yl]-methyltriphenylphosphonium bromide (0.5 g), 1-benzyl-2-imidazolecarbaldehyde (0.2 g) and potassium tert-butoxide (0.1 g) in tetrahydrofuran (5.0 ml) was refluxed for 50 minutes. Evaporation of a solvent gave a residue, which was purified by a column chromatography on silica gel eluting with a mixture of chloroform and methanol (19:1, V/V). The eluted fractions containing the desired product were collected and evaporated in vacuo to give 6-[2-(1-benzylimidazol-2-yl)vinyl]-2-ethylaminobenzoxazole (0.2 g).

1. temperaturewas refluxed for 50 minutes
2. customEvaporation of a solvent
3. customgave a residue, which
4. customwas purified by a column chromatography on silica gel eluting with a mixture of chloroform and methanol (19:1, V/V)
5. additionThe eluted fractions containing the desired product
6. customwere collected
7. customevaporated in vacuo