Ethyl Acetate → HCID 19823316, compound

HRID 728183Notes

Reaction equation

HRID 728183 reaction equation
[Cl:1][CH2:2][C:3]1[N:4]=[C:5]2[CH:10]=[C:9]([CH3:11])[CH:8]=[CH:7][N:6]2[CH:12]=1.[NH2:13][C:14]([NH2:16])=[S:15].C(OCC)(=O)C>C(O)C>[ClH:1].[CH3:11][C:9]1[CH:8]=[CH:7][N:6]2[CH:12]=[C:3]([CH2:2][S:15][C:14](=[NH:13])[NH2:16])[N:4]=[C:5]2[CH:10]=1

Participants

5

Reactant 3

HCID 8857Ethyl AcetateHCID 2723790ThioureaHCID 140427782-(Chloromethyl)-7-methylimidazo[1,2-a]pyridine

Product 1

HCID 19823316HCID 19823316, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 2-chloromethyl-7-methylimidazo[1,2-a]pyridine (5.0 g) and thiourea (2.2 g) in ethanol (10 ml) was refluxed for 20 minutes and the mixture was added to a ethyl acetate (100 ml) under stirring. The isolated precipitate was collected by filtration and washed with ethyl acetate to give S-(7-methylimidazo[1,2-a]pyridin-2-ylmethyl)isothiourea hydrochloride (7.11 g).

Workup

  1. temperaturewas refluxed for 20 minutes
  2. filtrationThe isolated precipitate was collected by filtration
  3. washwashed with ethyl acetate

Sources & evidence

ORD record
ord-58db34b7e8f84e35a54288b7647e50fc
Source dataset
uspto-grants-1991_09
Patent number
US05047411

Reaction notes

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