Sodium Hydroxide → HCID 15684679, compound

HRID 728184Notes

Reaction equation

HRID 728184 reaction equation
Cl.[CH3:2][C:3]1[CH:8]=[CH:7][N:6]2[CH:9]=[C:10]([CH2:12][S:13]C(=N)N)[N:11]=[C:5]2[CH:4]=1.[OH-].[Na+]>O>[CH3:2][C:3]1[CH:8]=[CH:7][N:6]2[CH:9]=[C:10]([CH2:12][SH:13])[N:11]=[C:5]2[CH:4]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 19823316HCID 19823316, compound

Product 1

HCID 15684679HCID 15684679, compoundYield 78.6%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of S-(7-methylimidazo[1,2-a]pyridin-2-ylmethyl)isothiourea hydrochloride (7.7 g) and sodium hydroxide (1.2 g) in water (54 ml) was refluxed for 2 hours and the reaction mixture was extracted with ethyl acetate. The extract was washed with water, and dried over magnesium sulfate. The solvent was evaporated in vacuo to give 7-methylimidazo[1,2-a]pyridin-2-ylmethanethiol (4.2 g).

Workup

  1. temperaturewas refluxed for 2 hours
  2. extractionthe reaction mixture was extracted with ethyl acetate
  3. washThe extract was washed with water
  4. dry with materialdried over magnesium sulfate
  5. customThe solvent was evaporated in vacuo

Sources & evidence

ORD record
ord-15d999a17d2d4d2d8890cb47877575b3
Source dataset
uspto-grants-1991_09
Patent number
US05047411

Reaction notes

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