Dichloromethane → HCID 178505950, compound

HRID 72827Notes

Reaction equation

HRID 72827 reaction equation
[O:1]1[CH2:6][CH2:5][N:4]([C:7]2[CH:8]=[C:9]([F:33])[C:10]3[N:11](C(OC(C)(C)C)=O)[C:12]4[C:17]([S:18][C:19]=3[CH:20]=2)=[CH:16][C:15]([N:21]2[CH2:25][CH2:24][CH2:23][CH2:22]2)=[CH:14][CH:13]=4)[CH2:3][CH2:2]1.[Cl:34]CCl>>[Cl-:34].[O:1]1[CH2:2][CH2:3][N:4]([C:7]2[CH:8]=[C:9]([F:33])[C:10]3[C:19]([CH:20]=2)=[S+:18][C:17]2[C:12](=[CH:13][CH:14]=[C:15]([N:21]4[CH2:22][CH2:23][CH2:24][CH2:25]4)[CH:16]=2)[N:11]=3)[CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 6344DichloromethaneHCID 70895770HCID 70895770, compound

Product 1

HCID 178505950HCID 178505950, compound

Conditions

Temperature
40 °C

Procedure

To a solution 3-morpholino-7-(pyrrolidin-1-yl)-1-fluoro-10-Boc-phenothiazine (150 mg) in dichloromethane (10 mL) HCl (2 mL, 4 M solution in 1,4-dioxane)) was added. The reaction mixture was stirred at 40° C. for 3 h. Solvent was removed under vacuum. Product was purified by flash chromatography.

Workup

  1. customSolvent was removed under vacuum
  2. customProduct was purified by flash chromatography

Sources & evidence

ORD record
ord-98aba1761eca447791d9603b8ca1fd4f
Source dataset
uspto-grants-2014_09
Patent number
US08828986B2

Reaction notes

Loading…