Dichloromethane → HCID 178482910, compound

HRID 72830Notes

Reaction equation

HRID 72830 reaction equation
[CH3:1][N:2]([CH3:31])[C:3]1[CH:4]=[C:5]([F:30])[C:6]2[N:7](C(OC(C)(C)C)=O)[C:8]3[C:13]([S:14][C:15]=2[CH:16]=1)=[CH:12][C:11]([N:17]1[CH2:22][CH2:21][O:20][CH2:19][CH2:18]1)=[CH:10][CH:9]=3.[Cl:32]CCl>>[Cl-:32].[CH3:1][N:2]([CH3:31])[C:3]1[CH:4]=[C:5]([F:30])[C:6]2[C:15]([CH:16]=1)=[S+:14][C:13]1[C:8](=[CH:9][CH:10]=[C:11]([N:17]3[CH2:22][CH2:21][O:20][CH2:19][CH2:18]3)[CH:12]=1)[N:7]=2

Participants

3

Reactant 2

HCID 6344DichloromethaneHCID 70895830HCID 70895830, compound

Product 1

HCID 178482910HCID 178482910, compound

Conditions

Temperature
40 °C

Procedure

To a solution 3-dimethylamino-7-morpholino-1-fluoro-10-Boc-phenothiazine (15) (100 mg) in dichloromethane (10 mL) HCl (1 mL, 4 M solution in 1,4-dioxane)) was added. The reaction mixture was stirred at 40° C. for 3 h. Solvent was removed under vacuum. Product was purified by flash chromatography.

Workup

  1. customSolvent was removed under vacuum
  2. customProduct was purified by flash chromatography

Sources & evidence

ORD record
ord-e9bdc129581e4f1189be83baf8ed3d7a
Source dataset
uspto-grants-2014_09
Patent number
US08828986B2

Reaction notes

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