Dichloromethane → HCID 178505949, compound

HRID 72833Notes

Reaction equation

HRID 72833 reaction equation
C([N:8]1[CH2:14][CH2:13][CH2:12][N:11]([C:15]2[CH:16]=[C:17]([F:42])[C:18]3[N:19](C(OC(C)(C)C)=O)[C:20]4[C:25]([S:26][C:27]=3[CH:28]=2)=[CH:24][C:23]([N:29]2[CH2:34][CH2:33][O:32][CH2:31][CH2:30]2)=[CH:22][CH:21]=4)[CH2:10][CH2:9]1)(OC(C)(C)C)=O.[Cl:43]CCl>>[Cl-:43].[N:11]1([C:15]2[CH:16]=[C:17]([F:42])[C:18]3[C:27]([CH:28]=2)=[S+:26][C:25]2[C:20](=[CH:21][CH:22]=[C:23]([N:29]4[CH2:30][CH2:31][O:32][CH2:33][CH2:34]4)[CH:24]=2)[N:19]=3)[CH2:12][CH2:13][CH2:14][NH:8][CH2:9][CH2:10]1

Participants

3

Reactant 2

HCID 6344DichloromethaneHCID 70895826HCID 70895826, compound

Product 1

HCID 178505949HCID 178505949, compound

Conditions

Temperature
40 °C

Procedure

To a solution 3-(4-Boc-1,4-diazepan-1-yl)-7-morpholino-1-fluoro-10-Boc-phenothiazine (0.8 g) in dichloromethane (10 mL) HCl (2 mL, 4 M solution in 1,4-dioxane)) was added. The reaction mixture was stirred at 40° C. for 3 h. Solvent was removed under vacuum. Product was purified by flash chromatography.

Workup

  1. customSolvent was removed under vacuum
  2. customProduct was purified by flash chromatography

Sources & evidence

ORD record
ord-799ca0ef64124ef091dc3153921a7fe3
Source dataset
uspto-grants-2014_09
Patent number
US08828986B2

Reaction notes

Loading…