HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thiazole → 2-Methoxy-1-octadecylcarbamoylthio-3-(3-thiazoliniopropylsulfonylamino)propane iodide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thiazole | HCID 9256 | — |
| Reactant | 3-(3-Iodopropylsulfonylamino)-2-methoxy-1-octadecylcarbamoylthiopropane | HCID 14835034 | — |
| Product | 2-Methoxy-1-octadecylcarbamoylthio-3-(3-thiazoliniopropylsulfonylamino)propane iodide | HCID 86745049 | 37% |
Reaction Steps
A solution of 76 mg of 3-(3-iodopropylsulfonylamino)-2-methoxy-1-octadecylcarbamoylthiopropane IIa6 in 1 ml of thiazole is heated at 60° C. for 6 hours. After the solvent is evaporated, the residue is washed with ether and subsequently with acetonitrile to give 32 mg of 2-methoxy-1-octadecylcarbamoylthio-3-(3-thiazoliniopropylsulfonylamino)propane iodide Ia26 in 37% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05047540 |
| Source dataset | uspto-grants-1991_09 |
| ORD ID | ord-1137cbec9c5143e79b3afacebc64698c |
| Source note | uspto-grants-1991_09 |