HRID728435

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID9256

Thiazole

C3H3NS

反应SMILES：CCCCCCCCCCCCCCCCCCNC(=O)SCC(CNS(=O)(=O)CCCI)OC

HCID14835034

未命名化合物

PRODUCTS

产物

反应SMILES：CCCCCCCCCCCCCCCCCCNC(=O)SCC(CNS(=O)(=O)CCCC1[NH+]=CCS1)OC.[I-]

HCID86745049

未命名化合物

收率 37%

PROCEDURE

实验过程

A solution of 76 mg of 3-(3-iodopropylsulfonylamino)-2-methoxy-1-octadecylcarbamoylthiopropane IIa6 in 1 ml of thiazole is heated at 60° C. for 6 hours. After the solvent is evaporated, the residue is washed with ether and subsequently with acetonitrile to give 32 mg of 2-methoxy-1-octadecylcarbamoylthio-3-(3-thiazoliniopropylsulfonylamino)propane iodide Ia26 in 37% yield.

WORKUP

后处理

customAfter the solvent is evaporated
washthe residue is washed with ether and subsequently with acetonitrile

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-1137cbec9c5143e79b3afacebc64698c
来源数据集: uspto-grants-1991_09
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US05047540
来源说明: uspto-grants-1991_09

反应SMILES

[I:1][CH2:2][CH2:3][CH2:4][S:5]([NH:8][CH2:9][CH:10]([O:34][CH3:35])[CH2:11][S:12][C:13](=[O:33])[NH:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH3:32])(=[O:7])=[O:6].[S:36]1[CH:40]=[CH:39][N:38]=[CH:37]1>>[I-:1].[CH3:35][O:34][CH:10]([CH2:9][NH:8][S:5]([CH2:4][CH2:3][CH2:2][CH:37]1[NH+:38]=[CH:39][CH2:40][S:36]1)(=[O:7])=[O:6])[CH2:11][S:12][C:13](=[O:33])[NH:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH3:32]