Phthalimide → 2-Methoxycarbonylamino-3-octadecylcarbamoyloxypropylamine

HRID 728446Notes

Reaction equation

HRID 728446 reaction equation
CO[NH:3][C:4]([CH:6]([CH2:9][O:10][C:11](=[O:31])[NH:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH3:30])CO)=O.C(SC[CH:50]([O:53]C)CN)CCCCCCCCCCCCCCC.[C:55]1(=[O:65])[NH:59]C(=O)C2=CC=CC=C12>>[CH3:50][O:53][C:55]([NH:59][CH:6]([CH2:9][O:10][C:11](=[O:31])[NH:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH3:30])[CH2:4][NH2:3])=[O:65]

Participants

4

Reactant 3

HCID 6809PhthalimideHCID 149922653-Hexadecylthio-2-methoxypropylamineHCID 198842322-Methoxycarbamoyl-3-octadecylcarbamoyloxypropanol

Product 1

HCID 148350002-Methoxycarbonylamino-3-octadecylcarbamoyloxypropylamine

Procedure

2-Methoxycarbamoyl-3-octadecylcarbamoyloxypropanol Ve1 is allowed to react and worked up by the same procdure as described in (3). The phthalimide derivative: m.p. 128°-129° C., the amine derivative: 85°-86° C. The summary of the experimental condition and the physical data of the product are listed in Tables 5 and 6.

Workup

  1. customto react
  2. custom85°-86° C

Sources & evidence

ORD record
ord-be344987158e4743ac1ce55e2b11c19e
Source dataset
uspto-grants-1991_09
Patent number
US05047540

Reaction notes

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