2-(2-Benzoyloxypropan-1-yl)-3-octadecylcarbamoyloxypropylamine → 2-Cyanomethyl-3-octadecylcarbamoyloxypropylamine

HRID 728504Notes

Reaction equation

HRID 728504 reaction equation
[N:1]([CH2:4][CH:5]([CH2:29][C:30]#[N:31])[CH2:6][O:7][C:8](=[O:28])[NH:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])=[N+]=[N-].C(OC(C)CC(COC(=O)NCCCCCCCCCCCCCCCCCC)CN)(=O)C1C=CC=CC=1>[Pd].CO>[C:30]([CH2:29][CH:5]([CH2:6][O:7][C:8](=[O:28])[NH:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])[CH2:4][NH2:1])#[N:31]

Participants

5

Reactant 2

HCID 148350122-(2-Benzoyloxypropan-1-yl)-3-octadecylcarbamoyloxypropylamineHCID 544340951-Azido-2-cyanomethyl-3-octadecylcarbamoyloxypropane

Product 1

HCID 148350142-Cyanomethyl-3-octadecylcarbamoyloxypropylamine

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture of 1-azido-2-cyanomethyl-3-octadecylcarbamoyloxypropane Vn2b, 80 mg of 10% palladium on charcoal in 40 ml of methanol is hydrogenated by the same procedure as described in (129) and crude product of the titled compound IVn2 is obtained.

Sources & evidence

ORD record
ord-4b70a0b57e6940cdbea92491340a5218
Source dataset
uspto-grants-1991_09
Patent number
US05047540

Reaction notes

Loading…