反应详情

温度

0 °C

Into a one liter reactor fitted with stirring, cooling and warming means and placed under nitrogen circulation were poured 30 ml of dimethylformamide, 20.3 g (0.055 mol) of 6-(2-chlorophenyl)-7, 8, 9, 10 -tetrahydro-1-methyl-4H-pyrido [4',3':4,5] thieno [3,2-f] 1,2,4-triazolo [4,3-a] 1,4-diazepine and 8.9 g (0.058 mol) of isopropyl-thio-acetic acid. After cooling the mixture to 0° C., there were slowly added, under stirring, 12.36 g (0.058 mol) of dicyclohexylcarbodiimide. Stirring was maintained for 4 hours at 0° C. and then for one hour after the reaction mixture had reached room temperature. There were then added 2 g of dicyclohexylcarbodiimide and the mixture was stirred overnight.

1. customInto a one liter reactor fitted
2. temperaturecooling
3. temperaturewarming means
4. additionthere were slowly added
5. stirringunder stirring
6. stirringStirring
7. temperaturewas maintained for 4 hours at 0° C.
8. stirringthe mixture was stirred overnight