4-Thiazoleacetic acid, 2-amino-alpha-oxo- → HCID 88527855, compound

HRID 728593Notes

Reaction equation

HRID 728593 reaction equation
[CH3:1][N:2]1[CH:6]=[CH:5][N:4]=[C:3]1[CH2:7][O:8][NH2:9].[NH2:10][C:11]1[S:12][CH:13]=[C:14]([C:16](=O)[C:17]([OH:19])=[O:18])[N:15]=1>>[NH2:10][C:11]1[S:12][CH:13]=[C:14](/[C:16](=[N:9]/[O:8][CH2:7][C:3]2[N:2]([CH3:1])[CH:6]=[CH:5][N:4]=2)/[C:17]([OH:19])=[O:18])[N:15]=1

Participants

3

Reactant 2

HCID 127833204-Thiazoleacetic acid, 2-amino-alpha-oxo-HCID 19788497HCID 19788497, compound

Product 1

HCID 88527855HCID 88527855, compound

Procedure

N.m.r. in solvent B: 4.73 (q, 2H), 6.93 (s, 1H). 15. The method of condensation was that described in Footnote 11. 16. N.m.r. in solvent B: 3.5 (d, 1H), 3.75 (d, 1H), 3.95 (d, 1H), 4.5 (d, 1H), 4.75 (d, 1H), 4.95 (d, 1H), 5.3 (d, 1H), 5.9 (d, 1H), 7.2 (s, 1H). 17. The starting material was prepared by reaction of O-(1-methylimidazol-2-yl)methylhydroxylamine with 2-(2-aminothiazol-4-yl)glyoxylic acid to give 2-(2-aminothiazol-4-yl)-2-[(Z)-(1-methylimidazol-2-yl)-methoxy-imino]acetic acid.

Workup

  1. customThe method of condensation

Sources & evidence

ORD record
ord-ef08ec3ffb03464cac089f4ce020e6d7
Source dataset
uspto-grants-1991_09
Patent number
US05049558

Reaction notes

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