Levemopamil → HCID 11771582, compound

HRID 728595Notes

Reaction equation

HRID 728595 reaction equation
[CH:1]([C@:4]([C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)([CH2:7][CH2:8][CH2:9][N:10](C)[CH2:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:5]#[N:6])([CH3:3])[CH3:2].ClC(OC=C)=O>ClCCl>[CH:1]([C@:4]([C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1)([CH2:7][CH2:8][CH2:9][NH:10][CH2:11][CH2:12][C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1)[C:5]#[N:6])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 72027LevemopamilHCID 78808Vinyl chloroformate

Product 1

HCID 11771582HCID 11771582, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

A solution of 17 g (50 mmol) of (S)-2-isopropyl-5-(methylphenethylamino)-2-phenylvaleronitrile in 50 ml of dichloromethane was added dropwise, at 0° C., to a solution of 6 ml (66 mmol) of vinyl chloroformate in 30 ml of dichloromethane. The temperature was then allowed to increase to room temperature, and the mixture was heated for 1 hour at 80° C.

Workup

  1. temperaturethe mixture was heated for 1 hour at 80° C.

Sources & evidence

ORD record
ord-bc93c88d34fe47dbb5c1a9318534d6df
Source dataset
uspto-grants-1991_09
Patent number
US05049583

Reaction notes

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