反应详情

To the crude 2-acetoxymethyl-4-cyclopropylmethoxy pyridine, NaOH (100 ml 2 M) was added and the mixture was refluxed for 2 hours. The mixture was extracted with methylene chloride, and the phases were separated. The organic layer was dried with Na2SO4, filtered and the solvent was evaporated off, yielding 2.7 g of crude title compound. NMR data is given below. The crude product was used without any further purification.

1. temperaturethe mixture was refluxed for 2 hours
2. extractionThe mixture was extracted with methylene chloride
3. customthe phases were separated
4. dry with materialThe organic layer was dried with Na2SO4
5. filtrationfiltered
6. customthe solvent was evaporated off