2-Acetoxymethyl-4-cyclopropylmethoxy pyridine → 4-Cyclopropylmethoxy-2-hydroxymethylpyridine

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Reaction Steps

To the crude 2-acetoxymethyl-4-cyclopropylmethoxy pyridine, NaOH (100 ml 2 M) was added and the mixture was refluxed for 2 hours. The mixture was extracted with methylene chloride, and the phases were separated. The organic layer was dried with Na2SO4, filtered and the solvent was evaporated off, yielding 2.7 g of crude title compound. NMR data is given below. The crude product was used without any further purification.

Provenance & Evidence