反应详情

温度

80 °C

A flask was charged with sodium hydride (60% oil dispersion 158 m8, 3 mMol) which was then washed with hexanes before the addition of n-propanol (25 mL). (±)-cis-4-(2-Amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol from Example 4 (400 mg, 1.5 mmol) was added and the solution was stirred at 80° C. for 2 hours and the neutralized by the addition of 1.0 N HC1. Concentration of the solution afforded the crude product which was purified by elution from a silica gel column with 2% methanol-chloroform (350 mg, 81%). Crystallization of such a sample from ethanol-water gave an off-white powder, m.p. 97-99° C.

1. washwas then washed with hexanes before the addition of n-propanol (25 mL)
2. additionthe neutralized by the addition of 1.0 N HC1