反应详情

Fumaric acid (0.18 g) dissolved in 2-propanol (7.5 cc) under reflux is added to a solution of 10-[(2RS)-1-diethylamino-2-propyl]-N-(2-methylpropyl)-2-phenothiazinecarboxamide (0.62 g) in boiling 2-propanol (7.5 cc). The mixture is concentrated to dryness under reduced pressure (30 mm Hg; 4 kPa) at 40° C. and the residue is stirred in isopropyl ether (50 cc). The solid is separated by filtration on sintered glass, washed with isopropyl ether (10 cc) and dried under reduced pressure (5 mm Hg; 0.7 kPa) to give 10-[(2RS)-1-diethylamino-2-propyl]-N-(2-methylpropyl)-2-phenothiazinecarboxamide fumarate (0.64 g), m.p. 110° C.

1. temperatureunder reflux
2. concentrationThe mixture is concentrated to dryness under reduced pressure (30 mm Hg; 4 kPa) at 40° C.
3. customThe solid is separated by filtration on sintered glass
4. washwashed with isopropyl ether (10 cc)
5. customdried under reduced pressure (5 mm Hg; 0.7 kPa)