Pyridine → HCID 135617167, compound

HRID 728807Notes

Reaction equation

HRID 728807 reaction equation
[NH2:1][C:2]1[N:3]([CH2:13][C:14]2[S:15][CH:16]=[CH:17][CH:18]=2)[C:4]2[N:5]=[C:6]([NH2:12])[NH:7][C:8](=[O:11])[C:9]=2[N:10]=1.CN([CH:22]=[O:23])C.N1C=CC=C[CH:25]=1.[C:30](OC(=O)C)(=[O:32])[CH3:31]>CCOCC>[O:11]=[C:8]1[NH:7][C:6]([NH:12][C:30](=[O:32])[CH3:31])=[N:5][C:4]2[N:3]([CH2:13][C:14]3[S:15][CH:16]=[CH:17][CH:18]=3)[C:2]([NH:1][C:22](=[O:23])[CH3:25])=[N:10][C:9]1=2

Participants

6

Reactant 4

HCID 1049PyridineHCID 6228DimethylformamideHCID 7918Acetic AnhydrideHCID 1354009088-Amino-9-(2-thienylmethyl)guanine

Product 1

HCID 135617167HCID 135617167, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A mixture of 8-amino-9-[(2-thienyl)methyl]guanine (0.5 g; 1.88 mmol), DMF (10 ml), pyridine (5 ml), and acetic anhydride (5 ml) was stirred at room temperature for 36 hours. The mixture was diluted with ether (50 ml) and filtered to give analytically pure product, mp 243°-4° C.

Workup

  1. filtrationfiltered
  2. customto give analytically pure product, mp 243°-4° C.

Sources & evidence

ORD record
ord-3db178947dc44278be106856db1a09e4
Source dataset
uspto-grants-1991_09
Patent number
US05051429

Reaction notes

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