Hydrochloric Acid → 2-[4-(1H-Imidazol-1-yl)phenoxy]ethanamine dihydrochloride

Participants

Reaction Steps

To 40 mL of 2M aqueous hydrochloric acid add 10.3 g (39 mmol) of N-[2-[4-(1H-imidazol-1-yl)phenoxy]ethyl]propionamide. Reflux the reaction mixture. Monitor the progress of the reaction by thin-layer chromatographyon silica gel (9:1, CH2Cl2 :MeOH). Upon completion of the reaction, remove the solvent in vacuo and triturate with isopropanol. Recrystallization of the resulting solid from ethanol affords the title compound.

Provenance & Evidence