反应详情

To 40 mL of 2M aqueous hydrochloric acid add 10.3 g (39 mmol) of N-[2-[4-(1H-imidazol-1-yl)phenoxy]ethyl]propionamide. Reflux the reaction mixture. Monitor the progress of the reaction by thin-layer chromatographyon silica gel (9:1, CH2Cl2 :MeOH). Upon completion of the reaction, remove the solvent in vacuo and triturate with isopropanol. Recrystallization of the resulting solid from ethanol affords the title compound.

1. temperatureReflux the reaction mixture
2. customMonitor the progress of the reaction by thin-layer chromatographyon silica gel (9:1, CH2Cl2 :MeOH)
3. customUpon completion of the reaction
4. customremove the solvent in vacuo
5. customtriturate with isopropanol
6. customRecrystallization of the resulting solid from ethanol