Phenyl glycidyl ether → HCID 53680309, compound

HRID 728816Notes

Reaction equation

HRID 728816 reaction equation
[CH2:1]([NH:4][C:5](=[O:17])[C:6]1[CH:11]=[CH:10][C:9]([NH:12][S:13]([CH3:16])(=[O:15])=[O:14])=[CH:8][CH:7]=1)[CH2:2][CH3:3].[O:18]1[CH:20]([CH2:21][O:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH2:19]1>CO>[OH:18][CH:20]([CH2:21][O:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[CH2:19][N:4]([CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[CH2:1][CH2:2][N:4]([CH2:1][CH2:2][CH3:3])[C:5](=[O:17])[C:6]1[CH:7]=[CH:8][C:9]([NH:12][S:13]([CH3:16])(=[O:14])=[O:15])=[CH:10][CH:11]=1

Participants

4

Reactant 2

HCID 31217Phenyl glycidyl etherHCID 2978254HCID 2978254, compound

Product 1

HCID 53680309HCID 53680309, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 7.95 9 (20 mmol) N-[2-(phenylmethyl)amino)ethyl]-N-propyl-4-[(methylsulfonyl)amino]benzamide in 20 mL 10% aqueous methanol is added 2.89 mL (21 mmol) 1,2-epoxy-3-phenoxypropane. The solution is stirred at room temperature for 24 h. After this time, the solvents are evaporated and the title compound is obtained as a foamy solid via column chromatography on silica gel (hexane:acetone, 9:1).

Workup

  1. customAfter this time, the solvents are evaporated

Sources & evidence

ORD record
ord-099b1835c9d3446880614f1eff4f31fe
Source dataset
uspto-grants-1991_09
Patent number
US05051423

Reaction notes

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