Hydrochloric Acid → HCID 67689860, compound

HRID 728820Notes

Reaction equation

HRID 728820 reaction equation
[N:1]1([C:6]2[CH:20]=[CH:19][C:9]([O:10][CH2:11][C:12]([NH:15]C(=O)C)([CH3:14])[CH3:13])=[CH:8][CH:7]=2)[CH:5]=[CH:4][N:3]=[CH:2]1.[ClH:21]>>[ClH:21].[ClH:21].[N:1]1([C:6]2[CH:20]=[CH:19][C:9]([O:10][CH2:11][C:12]([CH3:14])([CH3:13])[NH2:15])=[CH:8][CH:7]=2)[CH:5]=[CH:4][N:3]=[CH:2]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 54536771HCID 54536771, compound

Product 1

HCID 67689860HCID 67689860, compound

Procedure

Dissolve 27.0 g (0.106 mol) of N-[-2-[4-(1H-imidazol-1-yl)phenoxy]-1,1-dimethylethyl]acetamide in 270 mL of 2 N of hydrochloric acid and heat to reflux for 18 h. After this time, remove the water on the rotary evaporator and redissolve the residue in 50mL of isopropanol. Remove the isopropanol on a rotary evaporator and suspend the resulting solid in diethyl ether. Filter off the solid to provide the title compound.

Workup

  1. temperatureheat
  2. temperatureto reflux for 18 h
  3. customAfter this time, remove the water
  4. customon the rotary evaporator
  5. dissolutionredissolve the residue in 50mL of isopropanol
  6. customRemove the isopropanol
  7. customon a rotary evaporator
  8. filtrationFilter off the solid

Sources & evidence

ORD record
ord-0fb5cd22eced4b6183422b5ce81099ce
Source dataset
uspto-grants-1991_09
Patent number
US05051423

Reaction notes

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