HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → N-[4-[[2-Hydroxy-3-(3-methylphenoxy)propyl]aminomethyl]phenyl]methanesulfonamide hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Phenyl glycidyl ether | HCID 31217 | — |
| Reactant | 4-(Methylsulfonylamino)benzylamine hydrochloride | HCID 2760996 | — |
| Solvent | Potassium Hydroxide | HCID 14797 | — |
| Product | N-[4-[[2-Hydroxy-3-(3-methylphenoxy)propyl]aminomethyl]phenyl]methanesulfonamide hydrochloride | HCID 67689925 | — |
Reaction Steps
Heat a mixture of N-[4-(aminomethyl)phenyl]methanesulfonamide hydrochloride(15.0 g, 63.4 mmol) and 1,2-epoxy-3-phenoxypropane (10.41 g, 63.4 mmol) in 63.4 mL of 1 N KOH in methanol and 10 mL of water for about 3.5 h. Remove the solvent to afford crystals of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05051423 |
| Source dataset | uspto-grants-1991_09 |
| ORD ID | ord-a803a23f20484de38099ab35d2c71d98 |
| Source note | uspto-grants-1991_09 |