2,3-Epoxypropyl 4'-methoxyphenyl ether → HCID 14739881, compound

HRID 728827Notes

Reaction equation

HRID 728827 reaction equation
[O:1]1[CH:3]([CH2:4][O:5][C:6]2[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[CH:8][CH:7]=2)[CH2:2]1.[NH2:14][CH2:15][CH2:16][NH:17][C:18](=[O:30])[C:19]1[CH:24]=[CH:23][C:22]([N:25]2[CH:29]=[CH:28][N:27]=[CH:26]2)=[CH:21][CH:20]=1>CO>[OH:1][CH:3]([CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[CH:8][CH:7]=1)[CH2:2][NH:14][CH2:15][CH2:16][NH:17][C:18](=[O:30])[C:19]1[CH:24]=[CH:23][C:22]([N:25]2[CH:29]=[CH:28][N:27]=[CH:26]2)=[CH:21][CH:20]=1

Participants

4

Reactant 2

HCID 166462,3-Epoxypropyl 4'-methoxyphenyl etherHCID 14664358N-(2-Aminoethyl)-4-(1H-imidazol-1-yl)benzamide

Product 1

HCID 14739881HCID 14739881, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 2.39 g (13.2 mmol) 1,2-epoxy-3-(4-methoxyphenoxy)propane in 25 mL methanol is added 3.05 g (13.2 g) N-(2-aminoethyl)-4-(1H-imidazol-1-yl)benzamide. The reaction mixture is stirred under a nitrogen atmosphere for 24 h. After this time, the precipitate is collected and recrystallized from ethanol to provide the title compound.

Workup

  1. customAfter this time, the precipitate is collected
  2. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-38e8628e4cb44652858f6f795a33044a
Source dataset
uspto-grants-1991_09
Patent number
US05051423

Reaction notes

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