HRID728832

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID1004

Phosphoric acid

H3O4P

HCID14798

Sodium Hydroxide

HNaO

HCID92515

2,3-Epoxypropyl 4-(2-methoxyethyl)phenyl ether

C12H16O3

结构：CS(=O)(=O)Nc1ccc(C(=O)N2CCNCC2)cc1.Cl

HCID67938782

未命名化合物

PRODUCTS

生成物

结构：COCCc1ccc(OCC(O)CN2CCN(C(=O)c3ccc(NS(C)(=O)=O)cc3)CC2)cc1.O=P(O)(O)O

HCID67689897

未命名化合物

PROCEDURE

实验过程

Add 2.64 g (.013 mol) of 1,2-epoxy-3-[4-(2-methoxyethyl)phenoxy]propane to a solution of 3.86 (12 mmol) 1-[4-[(methylsulfonyl)amino]benzoyl]piperazine hydrochloride in 50 mL MeOHand 13 mL 1 N NaOH. Heat the resultant solution at 50° C. for about 24 h. Cool the solution to room temperature and evaporate the solvents. Dissolve the resultant oil in ethanol and acidify with one equivalent of phosphoric acid. Remove the solvents to obtain the title compound.

WORKUP

后处理

customevaporate the solvents
dissolutionDissolve the resultant oil in ethanol
customRemove the solvents

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-6572aa27bc024775a1289fd258b75283
来源数据集: uspto-grants-1991_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05051423
来源说明: uspto-grants-1991_09

反应 SMILES

[O:1]1[CH:3]([CH2:4][O:5][C:6]2[CH:11]=[CH:10][C:9]([CH2:12][CH2:13][O:14][CH3:15])=[CH:8][CH:7]=2)[CH2:2]1.Cl.[CH3:17][S:18]([NH:21][C:22]1[CH:35]=[CH:34][C:25]([C:26]([N:28]2[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]2)=[O:27])=[CH:24][CH:23]=1)(=[O:20])=[O:19].[OH-].[Na+].[P:38](=[O:42])([OH:41])([OH:40])[OH:39]>>[P:38](=[O:39])([OH:42])([OH:41])[OH:40].[OH:1][CH:3]([CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([CH2:12][CH2:13][O:14][CH3:15])=[CH:8][CH:7]=1)[CH2:2][N:31]1[CH2:32][CH2:33][N:28]([C:26](=[O:27])[C:25]2[CH:34]=[CH:35][C:22]([NH:21][S:18]([CH3:17])(=[O:20])=[O:19])=[CH:23][CH:24]=2)[CH2:29][CH2:30]1