Phosphoric Acid → HCID 67689897, compound

HRID 728832Notes

Reaction equation

HRID 728832 reaction equation
[O:1]1[CH:3]([CH2:4][O:5][C:6]2[CH:11]=[CH:10][C:9]([CH2:12][CH2:13][O:14][CH3:15])=[CH:8][CH:7]=2)[CH2:2]1.Cl.[CH3:17][S:18]([NH:21][C:22]1[CH:35]=[CH:34][C:25]([C:26]([N:28]2[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]2)=[O:27])=[CH:24][CH:23]=1)(=[O:20])=[O:19].[OH-].[Na+].[P:38](=[O:42])([OH:41])([OH:40])[OH:39]>>[P:38](=[O:39])([OH:42])([OH:41])[OH:40].[OH:1][CH:3]([CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([CH2:12][CH2:13][O:14][CH3:15])=[CH:8][CH:7]=1)[CH2:2][N:31]1[CH2:32][CH2:33][N:28]([C:26](=[O:27])[C:25]2[CH:34]=[CH:35][C:22]([NH:21][S:18]([CH3:17])(=[O:20])=[O:19])=[CH:23][CH:24]=2)[CH2:29][CH2:30]1

Participants

5

Reactant 4

HCID 1004Phosphoric AcidHCID 14798Sodium HydroxideHCID 92515((p-(2-Methoxyethyl)phenoxy)methyl)oxiraneHCID 679387821-[4-[(Methylsulfonyl)amino]benzoyl]piperazine hydrochloride

Product 1

HCID 67689897HCID 67689897, compound

Procedure

Add 2.64 g (.013 mol) of 1,2-epoxy-3-[4-(2-methoxyethyl)phenoxy]propane to a solution of 3.86 (12 mmol) 1-[4-[(methylsulfonyl)amino]benzoyl]piperazine hydrochloride in 50 mL MeOHand 13 mL 1 N NaOH. Heat the resultant solution at 50° C. for about 24 h. Cool the solution to room temperature and evaporate the solvents. Dissolve the resultant oil in ethanol and acidify with one equivalent of phosphoric acid. Remove the solvents to obtain the title compound.

Workup

  1. customevaporate the solvents
  2. dissolutionDissolve the resultant oil in ethanol
  3. customRemove the solvents

Sources & evidence

ORD record
ord-6572aa27bc024775a1289fd258b75283
Source dataset
uspto-grants-1991_09
Patent number
US05051423

Reaction notes

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