反应详情

To tert-butyl 8-(2,2-difluoroethyl)-10-(4-methyl-1H-pyrazol-5-yl)-11-oxa-3,8-diazaspiro[5.5]undecane-3-carboxylate (80 mg, 0.20 mmol) in ethanol (0.2 mL) was added HCl (500 μL of 4 M in dioxane, 2.00 mmol) and the reaction mixture was stirred for 1 hour. The reaction mixture was concentrated in vacuo to give, 8-(2,2-difluoroethyl)-10-(4-methyl-1H-pyrazol-5-yl)-11-oxa-3,8-diazaspiro[5.5]undecane hydrochloride salt as a yellow solid. ESI-MS m/z calc. 300.2. Found 301.3 (M+1)+; Retention time: 0.48 minutes (3 min run). 1H NMR (400 MHz, DMSO) δ 8.74 (s, 2H), 7.45 (s, 1H), 6.49-6.08 (m, 1H), 5.76 (s, 1H), 4.88 (d, J=9.6 Hz, 1H), 3.21-2.57 (m, 10H), 2.06 (s, 3H), 1.81-1.56 (m, 4H).

1. concentrationThe reaction mixture was concentrated in vacuo
2. customto give
3. customRetention time: 0.48 minutes (3 min run)