Hydrochloric Acid → HCID 54534355, compound

HRID 728843Notes

Reaction equation

HRID 728843 reaction equation
[NH2:1][CH:2](/[CH:6]=[CH:7]/[CH2:8][P:9]([OH:12])([OH:11])=[O:10])[C:3]([OH:5])=[O:4].Cl.[CH2:14](O)[CH3:15]>>[CH2:14]([O:4][C:3](=[O:5])[CH:2]([NH2:1])[CH:6]=[CH:7][CH2:8][P:9]([OH:12])([OH:11])=[O:10])[CH3:15]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 6506250HCID 6506250, compound

Product 1

HCID 54534355HCID 54534355, compound

Procedure

2.0 g of E-2-amino-5-phosphono-3-pentenoic acid are placed in 50 ml of ethanol and the whole is saturated with hydrogen chloride gas for 21/2 hours at 50°. After concentration, the residue is dissolved in 18 ml of ethanol, 18 ml of propylene oxide are added and the precipitate is filtered off. Recrystallisation from water/ethanol 1:3 yields 2-amino-5-phosphono-3-pentenoic acid ethyl ester, m.p. 167°-168°.

Workup

  1. custom2 hours
  2. customat 50°
  3. concentrationAfter concentration
  4. dissolutionthe residue is dissolved in 18 ml of ethanol
  5. addition18 ml of propylene oxide are added
  6. filtrationthe precipitate is filtered off
  7. customRecrystallisation from water/ethanol 1:3

Sources & evidence

ORD record
ord-8015e71d86894ff9b0c20ec652666338
Source dataset
uspto-grants-1991_09
Patent number
US05051413

Reaction notes

Loading…