Triethylamine → 4-Benzyl-2-cyano-1-phenylpiperazine

HRID 728911Notes

Reaction equation

HRID 728911 reaction equation
[C:1]1([NH:7][CH2:8][CH2:9][NH:10][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.BrC(CBr)[C:20]#[N:21].[CH2:24](N(CC)CC)[CH3:25]>C1(C)C=CC=CC=1>[C:1]1([N:7]2[CH2:25][CH2:24][N:10]([CH2:11][C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[CH2:9][CH:8]2[C:20]#[N:21])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 1072992,3-DibromopropanenitrileHCID 5302982N-benzyl-N'-phenylethane-1,2-diamine

Product 1

HCID 149987524-Benzyl-2-cyano-1-phenylpiperazine

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

In a manner similar to Preparation 1, react N-phenyl-N'-(phenylmethyl)-1,2-ethanediamine (0.41 g, 1.8 mmol) with 2,3-dibromopropanenitrile (0.77 g, 3.6 mmol) in toluene (5 mL) with triethylamine (0.73 g, 0.72 mmol) to obtain the title compound.

Workup

  1. customIn a manner similar to Preparation 1

Sources & evidence

ORD record
ord-57e5c0fe079648d384b64787686241f2
Source dataset
uspto-grants-1991_09
Patent number
US05051422

Reaction notes

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