4-Benzyl-2-cyano-1-phenylpiperazine → 1-Phenyl-4-(phenylmethyl)-2-piperazinemethanamine

HRID 728912Notes

Reaction equation

HRID 728912 reaction equation
[C:1]1([N:7]2[CH2:12][CH2:11][N:10]([CH2:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[CH2:9][CH:8]2[C:20]#[N:21])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[C:1]1([N:7]2[CH2:12][CH2:11][N:10]([CH2:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[CH2:9][CH:8]2[CH2:20][NH2:21])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 149987524-Benzyl-2-cyano-1-phenylpiperazineHCID 21226445Aluminium lithium hydride

Product 1

HCID 149987701-Phenyl-4-(phenylmethyl)-2-piperazinemethanamine

Procedure

In a manner similar to Preparation 2, react 1-phenyl-4-(phenylmethyl)-2-piperazinecarbonitrile (16.6 g, 60 mmol) with lithium aluminum hydride (6.8 g, 180 mmol) to obtain the title compound.

Workup

  1. customIn a manner similar to Preparation 2

Sources & evidence

ORD record
ord-347d02fb057a4f46b75e25381f1c3c18
Source dataset
uspto-grants-1991_09
Patent number
US05051422

Reaction notes

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