4-[(Methylsulfonyl)amino]benzoyl chloride → 4-[(Methylsulfonyl)amino]-N-[[1-phenyl-4-(phenylmethyl)piperazin-2-yl]methyl] benzamide

HRID 728913Notes

Reaction equation

HRID 728913 reaction equation
[C:1]1([N:7]2[CH2:12][CH2:11][N:10]([CH2:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[CH2:9][CH:8]2[CH2:20][NH2:21])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:22][S:23]([NH:26][C:27]1[CH:35]=[CH:34][C:30]([C:31](Cl)=[O:32])=[CH:29][CH:28]=1)(=[O:25])=[O:24]>>[CH3:22][S:23]([NH:26][C:27]1[CH:35]=[CH:34][C:30]([C:31]([NH:21][CH2:20][CH:8]2[CH2:9][N:10]([CH2:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[CH2:11][CH2:12][N:7]2[C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)=[O:32])=[CH:29][CH:28]=1)(=[O:25])=[O:24]

Participants

3

Reactant 2

HCID 117911194-[(Methylsulfonyl)amino]benzoyl chlorideHCID 149987701-Phenyl-4-(phenylmethyl)-2-piperazinemethanamine

Product 1

HCID 149987864-[(Methylsulfonyl)amino]-N-[[1-phenyl-4-(phenylmethyl)piperazin-2-yl]methyl] benzamide

Procedure

In a manner similar to Preparation 3, react 1-phenyl-4-(phenylmethyl)-2-piperazinemethanamine (11.1 g, 40 mmol) with 4-[(methylsulfonyl)amino]benzoyl chloride (10.1 g, 43 mmol) to obtain the title compound.

Workup

  1. customIn a manner similar to Preparation 3

Sources & evidence

ORD record
ord-5137f1c335144990b044a94a386a8f4b
Source dataset
uspto-grants-1991_09
Patent number
US05051422

Reaction notes

Loading…