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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 728913Generated: October 29, 2026

4-[(Methylsulfonyl)amino]benzoyl chloride → 4-[(Methylsulfonyl)amino]-N-[[1-phenyl-4-(phenylmethyl)piperazin-2-yl]methyl] benzamide

https://huagongshe.com/reaction/728913

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-[(Methylsulfonyl)amino]benzoyl chlorideHCID 11791119—
Reactant1-Phenyl-4-(phenylmethyl)-2-piperazinemethanamineHCID 14998770—
Product4-[(Methylsulfonyl)amino]-N-[[1-phenyl-4-(phenylmethyl)piperazin-2-yl]methyl] benzamideHCID 14998786—

Reaction Steps

In a manner similar to Preparation 3, react 1-phenyl-4-(phenylmethyl)-2-piperazinemethanamine (11.1 g, 40 mmol) with 4-[(methylsulfonyl)amino]benzoyl chloride (10.1 g, 43 mmol) to obtain the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05051422
Source datasetuspto-grants-1991_09
ORD IDord-5137f1c335144990b044a94a386a8f4b
Source noteuspto-grants-1991_09