4-[(Methylsulfonyl)amino]benzoyl chloride → N-[[4-(2-Methoxyphenyl)-1-(phenylmethyl)piperazin-2-yl]methyl]4-[(methylsulfonyl)amino]benzamide hydrochloride

HRID 728923Notes

Reaction equation

HRID 728923 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[CH2:14][CH2:13][N:12]([CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH:11]([CH2:22][NH2:23])[CH2:10]1.[CH3:24][S:25]([NH:28][C:29]1[CH:37]=[CH:36][C:32]([C:33]([Cl:35])=[O:34])=[CH:31][CH:30]=1)(=[O:27])=[O:26]>>[ClH:35].[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[CH2:14][CH2:13][N:12]([CH2:15][C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH:11]([CH2:22][NH:23][C:33](=[O:34])[C:32]2[CH:36]=[CH:37][C:29]([NH:28][S:25]([CH3:24])(=[O:27])=[O:26])=[CH:30][CH:31]=2)[CH2:10]1

Participants

3

Reactant 2

HCID 117911194-[(Methylsulfonyl)amino]benzoyl chlorideHCID 149987724-(2-Methoxyphenyl)-1-(phenylmethyl)-2-piperazinemethanamine

Product 1

HCID 19755013N-[[4-(2-Methoxyphenyl)-1-(phenylmethyl)piperazin-2-yl]methyl]4-[(methylsulfonyl)amino]benzamide hydrochloride

Procedure

In a manner similar to Preparation 3, react 4-(2-methoxyphenyl)-1-(phenylmethyl)-2-piperazinemethanamine (3.8 g, 12 mmol) with 4-[(methylsulfonyl)amino]benzoyl chloride (3.2 g, 14 mmol) to give the title compound.

Workup

  1. customIn a manner similar to Preparation 3

Sources & evidence

ORD record
ord-27f9fd67ab0c4e4385f7a9419393a2b2
Source dataset
uspto-grants-1991_09
Patent number
US05051422

Reaction notes

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