HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-Piperazinecarboxylic acid,4-phenyl-1-(phenylmethyl)-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 1-Benzyl-4-phenyl-piperazine-2-carboxamide | HCID 10990097 | — |
| Solvent | Ethylene Glycol | HCID 174 | — |
| Product | 2-Piperazinecarboxylic acid,4-phenyl-1-(phenylmethyl)- | HCID 14998801 | — |
Reaction Steps
Suspend 4-phenyl-1-(phenylmethyl)-2-piperazinecarboxamide (14.5 g, 49 mmol)in ethylene glycol (400 mL) and add potassium hydroxide (27.5 g, 490 mmol).Heat this mixture to 150° C. for 18 h. After this time, remove the solvent in vacuo. Add 6M hydrochloric acid (81.5 mL, 0.49 mol) and water (300 mL) and filter the resultant solid to obtain the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05051422 |
| Source dataset | uspto-grants-1991_09 |
| ORD ID | ord-d1cdf371fdc84ebdaeb2c748844826df |
| Source note | uspto-grants-1991_09 |